The No. 16 Louisville Cardinals (6-1) take on a conference opponent when they visit the Virginia Tech Hokies (3-5) on Saturday, November 1, 2025 at Lane Stadium in an ACC showdown.
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Louisville vs. Virginia Tech Matchup Info
- Game date: Saturday, November 1, 2025
- Game time: 3 p.m. ET
- Location: Blacksburg, Virginia
- Venue: Lane Stadium
- TV channel: The CW
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
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Louisville vs. Virginia Tech Odds and Prediction
- Spread favorite: Cardinals (-10.5)
- Moneyline: Cardinals (-410), Hokies (+321)
- Total: 52.5 points
- Pick ATS: Louisville (-10.5)
- Pick OU: Over (52.5)
- Prediction: Louisville 37, Virginia Tech 19
Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.
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Louisville vs. Virginia Tech Betting Records and Insights
- Louisville has won two games against the spread this season.
- Virginia Tech has covered just twice in eight matchups with a spread this year.
- The Cardinals have not covered the spread this season (0-4 ATS) when playing as at least 10.5-point favorites.
- The Hokies have not covered the spread this year (0-1 ATS) when playing as at least 10.5-point underdogs.
- Louisville and its opponent have combined to hit the over four out of seven times this season.
- In Virginia Tech's eight contests this year, the combined scoring has gone over the point total four times.