The Louisville Cardinals (4-0) and the No. 24 Virginia Cavaliers (4-1) square off on Saturday, October 4, 2025 at L&N Federal Credit Union Stadium in a battle of ACC foes.
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Louisville vs. Virginia Matchup Info
- Game date: Saturday, October 4, 2025
- Game time: 3:30 p.m. ET
- Location: Louisville, Kentucky
- Venue: L&N Federal Credit Union Stadium
- TV channel: ESPN2
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
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Louisville vs. Virginia Odds and Prediction
- Spread favorite: Cardinals (-6.5)
- Moneyline: Cardinals (-247), Cavaliers (+201)
- Total: 60.5 points
- Pick ATS: Louisville (-6.5)
- Pick OU: Over (60.5)
- Prediction: Louisville 34, Virginia 27
Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.
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Louisville vs. Virginia Betting Records and Insights
- Louisville has a record of 1-3-0 against the spread this season.
- Virginia is 4-1-0 ATS this season.
- The Cardinals have been favored by 6.5 points or more this season three times and failed to cover in all three.
- The Cavaliers have won their only game this season when playing as at least 6.5-point underdogs.
- Louisville and its opponent have combined to go over the point total three out of four times this season.
- In Virginia's five contests this season, the combined scoring has gone over the point total four times.